The original St. Louis Raceway Park was a 1/8-mile drag strip built in 1967 by Wayne Meinert. In1971 Meinert acquired additional land, extended the strip to a quarter mile, and renamed it St. Louis International Speedway.
The first road course was constructed in 1985. The 2.6 mile circuit was largely flat, with only a few small elevation changes, but the layout was unique; parts of the drag strip served as straights in two separate sections of the road course. The road course also crossed the drag strip deceleration zone at two points. The new circuit hosted a Trans Am Series race in 1985, Can-Am races in 1985 and 1986 and assorted Sports Car Club of America (SCCA) regional and national events.
A 1/20 mile dirt oval also began operation in 1985. The name was changed to Gateway International Raceway in 1988. In 1995 Chris Pook, promoter of the Formula 1 and CART races at Long Beach, purchased the facility. He demolished the old tracks, and began construction of the new oval, a new infield road course and a new drag strip.
In early January 2008, it was announced that the Missouri-Illinois Dodge Dealers would move their sponsorship from the NASCAR Craftsman Truck race to the NASCAR Nationwide Series race. The race would later be called the Missouri-Illinois Dodge Dealers 250. At the 2008 event, Carl Edwards became the fourth driver to win two NASCAR Nationwide Series events at Gateway.
At the 2008 Camping World 200, Gateway introduced its brand-new victory lane, a throwback to the one used at Rockingham. In 2009, two new events were added to the season schedule: The American Drag Racing League; a sanctioning body headquartered in nearby O’Fallon, Missouri, and the USAC .25 Midget Series, the racing league’s new quartermidget tour.
In 2010 Gateway received a second NASCAR Nationwide Series race due to the closure of Memphis Motorsports Park. On November 3, 2010, Dover Motorsports announced that Gateway was officially closing and ceasing all racing operations at the track. On Sept. 8, 2011, the official announcement was made that Gateway would re-open in 2012 as Gateway Motorsports Park and host the 15th Annual NHRA Midwest Nationals September 28 – 30, 2012.